Hi Helen, Heap and Perm issues are generally something I like to get involved in having come across many useful ways to see what is going on with the Java memory. However I do not immediately know what to think since you say Heap and Perm are adjusted and I gather you are not getting Java heap or perm errors anymore.
Since the change in CF10 to tomcat from Jrun (as used in CF7) I have noticed the connector log file handy to know if some other tuning issue is occurring. My environment is Windows IIS tho with Ubuntu Apache you are still using tomcat AJP and a connector. Any errors or warnings in CF10/config/N/mod_jk.log where N = number perhaps 1 and mod_jk.log maybe go by similar name?
HTH, Carl.