@etnevels1, note that one of the many things that CF10 update 11 addressed was an issue related to when CF was processing 404s for IIS. I know your note here was from March, but someone pointed me to this thread today, so I wanted to offer that if you'd not tried it.
And if it does not work, can you please confirm that the date on the aspnet_isapi.dll in your [cf10]\config\wsconfig\[n]\ folder(s) is from May 2013? If it's from March 2012, that too is a severe cause of problems. CF10 update 5 fixed that (for IIS and Apache), but anyone who applied that or a later update then NEEDS to rebuild the web server connectors (run the CF web server config tool, and remove and re-add all connections). And don't forget to run that tool by right-clicking and choosing "run as administrator".
To you or others with issues in this thread, please to clarify if you've updated to the latest build (11, as I write) and (more important) checked the date of that aspnet_isapi.dll (in ALL folders under wsconfig), before reporting any seeming ongoing issues?
Either really could be the simple solution to so many problems report with CF10 (on IIS and Apache). Hope that's helpful.