Depends on your requirements. I think you can probably research the pros and cons of each, although they can perhaps be summarised by thinking that a CMS would have its content maintained by a subset of people who manage the content for a broader audience of consumers who only read the information, whereas a wiki is aimed at consumers who both read and maintain the information.
As for CMSes... nup, never had the need to use one. However if you want a CFML-based one, I believe Mura is the way to go? Or perhaps ContentBox? I've never used either.
I'll try to get the guys from both to have a chat with you...
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Adam