Hello tribule,
Thank you for your post. The error 500 is a generic error thrown by IIS. IIS received the request; however, an internal error occurred during the processing of the request. The root cause of this error depends on which module handles the request and what was happening in the worker process when this error occurred.
One possibility is, IIS was not able to access the web.config file for the Web site or application. Please check the permissions.
The handlers might be causing the issue. Please remove the connector. Make sure you launch wsconfig with Run as Administrator while remove/adding connector. Check in the IIS manager for handlers, cgi restriction for connector dll entry (isapi_redirect.dll) and remove them manually if exist. Then only recreate the connector.
Also, please tune your application by applying the steps mentioned at http://blogs.coldfusion.com/post.cfm/tuning-coldfusion-10-iis-connecto r-configuration
Hope it helps.
Regards,
Anit Kumar