Re: New CF10, Server 2012, Default Document 404

My advice would be to delete your web.config altogether for this test site, and focus on the global IIS settings.  For example, check the Default Document settings for the entire Web farm (highest level) and make sure they are in the correct order.  Work your way from the top down.  Again, since you say you've already hardened CF (which is a massive subject by itself) it's too hard to say what's causing, so I would isolate IIS from CF as much as possible at this point.  Perhaps uninstall and reinstall CF.  Or just Google the issue for IIS8.  I have never used 2012 with IIS8 so I'm probably not the right person to go on much longer about it.  I will drop out at this point, but best of luck, and reply back when solved.