Hi Angela,
Are you able to access the the site with http://mydomain.com/ and http://mydomain.com/index.cfm both?
Please try adding the following information in web.config:-
<configuration>
<system.webServer>
<defaultDocument>
<files>
<add value="index.cfm" />
</files>
</defaultDocument>
</system.webServer>
</configuration>
Alternatively, enter the following at the command prompt:
appcmd set config /section:defaultDocument /+files.[value='index.cfm']
where index.cfm is the default document to be added. You may try restarting IIS after the above steps.
Regards,
Anit Kumar