I've discovered we're having the same issue as well I believe.
I just built a fresh Hyper-V Windows 2008 R2 IIS 7.5 with ColdFusion 10 patch 13 and the isapi connectors are all freshly built as the newest version (1.2.32 11/2/2013) and we run a connector per website and not All Websites. I have it running on the latest Oracle Java JRE 1.7.0_51 as well, all items 64bit. I currently have 2 users accessing this system and the IIS app pool associated with the ColdFusion portion keeps shutting down randomly. It did it 3 times today but yesterday not at all. This is a development system so the load is very small. I've also tried the connector tuning values above to no avail. I've also run through the CF10 hardening guide on this system.
The main portion of the website runs DotNetNuke in .NET4 and then CF10 is running as a virtual folder within the website on its own app pool. There is another website on this server that runs CF and is not crashing, however it does not have multiple app pools or .NET running in it.
I have another server where I have the majority of our existing development websites still which has a mixed CF9 & CF10 environment and we've never seen this issue on that system. After reading through this more though I believe that's because none of our websites currently evaluating CF10 on that server have mixed app pools and only run CF10 and no .NET in them.
To bring the CF portion back online is as easy as restarting the app pool or more drastically doing an iisreset. I've been testing out having a scheduled task run the IIS command to start the app pool to try to catch it if it fails and bring it back online. If the app pool is running the command does nothing so having this run frequently does no harm.
%windir%\system32\inetsrv\appcmd.exe start apppool /apppool.name:"MyAppPoolName"
I'm also going to experiment with the AppPool Rapid-Fail Protection settings to try changing the minutes & maximum failures to find a happy medium of protection and stability.
From reading the bug report https://bugbase.adobe.com/index.cfm?event=bug&id=3530880 it sounds like there's a fix coming.
Asha K S
7:37:04 AM GMT+00:00 Jan 25, 2014
@TheCycoONE it is not part of any CF 10 released patch yet.
Is there any ETA on this or a way of getting early test access?