If I may jump into this as I'm a bit confused at how ColdFusion 10 is now integrating with IIS 8. I've been fighting this for quite a few hours under the assumption that CF10 work similarly to CF9 but it appears that this is not the case?
To get CF 10 to work, I've removed all handler mappings and added the Jakarta virtual directory and boom, it's working.
Am I configured in a way that might compromise the server. Are handler mappings no longer being used and we're accessing everything through the Jakarta virtual directory?