@Citadelnetworks,
I would suggest starting over with IIS integration. There is an updated lockdown guide specifically for CF10: http://www.adobe.com/content/dam/Adobe/en/products/coldfusion/pdfs/cf1 0/cf10-lockdown-guide.pdf. The process includes the steps required to lock down IIS7.5 (and 8 should be similar enough), and the process is somewhat different than it was from CF9. Also, if you remove the Jakarta virtual directory manually, then run the Web Server Configuration Tool (WSCONFIG), it should wire up all of the required handlers and virtual directories. Again, have you downloaded the updated installers that specifically added support for IIS8 (Windows 8 and 2012)?
-Carl V.