You can have multiple datasources in your application. Create each one in your CF Admin > Datasources. Then in onApplicationStart in your application.cfc, just create each one, e.g.
<cfset application.customerDSN = "Customer_Datasource">
<cfset application.supplierDSN = "Supplier_Datasource">
Which you can then refer to in your queries or stored procedures:
<cfstoredproc datasource="#application.supplierDSN#">